76,360 XNAS Volume
XNAS 17 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 30,169 | 399,272 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 25,140 | 173,966 | - | 0 | Common Stock | |
| Markus W. Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 58,138 | 440,260 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 25,140 | 64,853 | - | 0 | Common Stock | |
| Shawn M. Cross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 28,597 | 136,346 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 70,329 | 419,100 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 33,311 | 179,137 | - | 0 | Common Stock | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 27,654 | 77,884 | - | 0 | Common Stock | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 63,608 | 369,103 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 15,145 | 148,826 | - | 0 | Common Stock | |
| Markus W. Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 35,022 | 382,122 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 15,145 | 39,713 | - | 0 | Common Stock | |
| Shawn M. Cross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 17,228 | 107,749 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 20,067 | 145,826 | - | 0 | Common Stock | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2024 | 16,660 | 50,230 | - | 0 | Common Stock | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 9,524 | 305,495 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 7,937 | 133,681 | - | 0 | Common Stock | |
| Markus W. Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 18,354 | 347,100 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 7,937 | 24,568 | - | 0 | Common Stock | |
| Shawn Cross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 9,028 | 90,521 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 10,516 | 125,759 | - | 0 | Common Stock | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2024 | 8,731 | 33,570 | - | 0 | Common Stock | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 9,375 | 295,971 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 7,813 | 125,744 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| N. Scott Fine | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 266,354 | 266,354 | - | - | Stock Option (Right to Buy) | |
| Markus W. Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| Markus W. Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 18,067 | 328,746 | - | 0 | Common Stock | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 110,732 | 110,732 | - | - | Stock Option (Right to Buy) | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 7,813 | 16,631 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| Shawn Cross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 8,887 | 81,493 | - | 0 | Common Stock | |
| Shawn Cross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| Joshua M. Fine | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 110,732 | 110,732 | - | - | Stock Option (Right to Buy) | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 10,743 | 348,771 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 10,352 | 115,243 | - | 0 | Common Stock | |
| Michael Lisjak | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 110,732 | 110,732 | - | - | Stock Option (Right to Buy) | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 15,562 | 15,562 | - | - | Stock Option (Right to Buy) | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 8,594 | 24,839 | - | 0 | Common Stock | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 6,963 | 286,596 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 6,330 | 8,818 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 8,703 | 338,028 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 8,466 | 117,931 | - | 0 | Common Stock | |
| Conkling William | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 6,330 | 16,245 | - | 0 | Common Stock | |
| M. Randall Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 7,516 | 104,891 | - | 0 | Common Stock | |
| Sieger Markus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 14,004 | 310,679 | - | 0 | Common Stock | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 8,089 | 228,825 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 9,835 | 99,483 | - | 0 | Common Stock | |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 16,269 | 220,282 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 10,111 | 259,182 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 8,732 | 88,513 | - | 0 | Common Stock | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2023 | 2,449 | 2,449 | - | 0 | Common Stock | |
| Vivien Wong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2023 | 6,700 | 6,700 | - | - | Stock Option (right to buy) | |
| William Conkling | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 21,360 | 220,736 | - | 0 | Common Stock | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 25,971 | 89,648 | - | 0 | Common Stock | |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 42,962 | 204,013 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 26,700 | 249,071 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 23,059 | 79,781 | - | 0 | Common Stock | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Apr 2023 | 299,402 | 299,402 | - | - | Warrant to Purchase Common Stock | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.71 per share. | 20 Apr 2023 | 299,402 | 444,402 | - | 0.7 | 212,575 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Apr 2023 | 59,881 | 59,881 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.71 per share. | 20 Apr 2023 | 59,881 | 161,051 | - | 0.7 | 42,516 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 0.71 per share. | 20 Apr 2023 | 29,941 | 62,101 | - | 0.7 | 21,258 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Apr 2023 | 29,941 | 29,941 | - | - | Warrant to Purchase Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Apr 2023 | 59,881 | 59,881 | - | - | Warrant to Purchase Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 0.71 per share. | 20 Apr 2023 | 59,881 | 222,371 | - | 0.7 | 42,516 | Common Stock |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,350 | 3,350 | - | - | Stock Option (Right to buy) | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,350 | 3,350 | - | - | Stock Option (Right to buy) | |
| N. Scott Fine | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 98,706 | 98,706 | - | - | Stock Option (Right to buy) | |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,350 | 3,350 | - | - | Stock Option (Right to buy) | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 41,036 | 41,036 | - | - | Stock Option (Right to buy) | |
| Joshua M. Fine | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 41,036 | 41,036 | - | - | Stock Option (Right to buy) | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,350 | 3,350 | - | - | Stock Option (Right to buy) | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 3,350 | 3,350 | - | - | Stock Option (Right to buy) | |
| Michael Lisjak | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 41,036 | 41,036 | - | - | Stock Option (Right to buy) | |
| Lise Lund Kjems | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2023 | 55,453 | 55,453 | - | - | Stock Option (Right to buy) | |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Nov 2022 | 9,496 | 101,170 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Nov 2022 | 11,803 | 162,490 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Nov 2022 | 5,097 | 56,722 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 1.76 per share. | 21 Sep 2022 | 5,000 | 150,687 | - | 1.8 | 8,800 | Common Stock |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2022 | 5,762 | 91,674 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2022 | 7,162 | 145,687 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2022 | 3,093 | 51,625 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 2.00 per share. | 20 May 2022 | 12 | 133,537 | - | 2 | 24 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 2.04 per share. | 20 May 2022 | 4,988 | 138,525 | - | 2.0 | 10,175 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 2.12 per share. | 16 May 2022 | 3,000 | 32,160 | - | 2.1 | 6,354 | Common Stock |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2022 | 4,223 | 85,912 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2022 | 5,249 | 133,525 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2022 | 5,249 | 133,525 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2022 | 2,267 | 48,532 | - | 0 | Common Stock | |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 2.50 per share. | 28 Apr 2022 | 635 | 27,795 | - | 2.5 | 1,588 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 2.70 per share. | 28 Apr 2022 | 300 | 28,095 | - | 2.7 | 810 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 2.71 per share. | 28 Apr 2022 | 1,065 | 29,160 | - | 2.7 | 2,882 | Common Stock |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 2.90 per share. | 06 Apr 2022 | 5,000 | 128,276 | - | 2.9 | 14,500 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 2.73 per share. | 29 Mar 2022 | 10,000 | 81,689 | - | 2.7 | 27,300 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 74,907 | 74,907 | - | - | Stock Options (Right to buy) | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 31,141 | 31,141 | - | - | Stock Options (Right to buy) | |
| Joshua M. Fine | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 31,141 | 31,141 | - | - | Stock Options (Right to buy) | |
| Michael Lisjak | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 31,141 | 31,141 | - | - | Stock Options (Right to buy) | |
| Lise Lund Kjems | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 31,141 | 31,141 | - | - | Stock Option (Right to buy) | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 3.58 per share. | 07 Feb 2022 | 10,334 | 145,000 | - | 3.6 | 36,996 | Common Stock |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 3.30 per share. | 04 Feb 2022 | 5,000 | 123,276 | - | 3.3 | 16,500 | Common Stock |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2022 | 4,075 | 71,689 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2022 | 5,065 | 118,276 | - | 0 | Common Stock | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2022 | 2,187 | 46,265 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 3.75 per share. | 24 Jan 2022 | 2,000 | 113,211 | - | 3.8 | 7,500 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 3.89 per share. | 19 Jan 2022 | 5,000 | 134,666 | - | 3.9 | 19,450 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.00 per share. | 19 Jan 2022 | 1,132 | 111,211 | - | 4 | 4,528 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.00 per share. | 14 Jan 2022 | 1,731 | 110,079 | - | 4 | 6,924 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.00 per share. | 14 Jan 2022 | 2,137 | 108,348 | - | 4 | 8,548 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 3.89 per share. | 15 Dec 2021 | 5,000 | 129,666 | - | 3.9 | 19,450 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 3.90 per share. | 15 Dec 2021 | 3,000 | 106,211 | - | 3.9 | 11,700 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.40 per share. | 10 Dec 2021 | 5,000 | 103,211 | - | 4.4 | 22,000 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 03 Dec 2021 | 864 | 98,211 | - | 4.8 | 4,104 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 4.93 per share. | 02 Dec 2021 | 5,000 | 124,666 | - | 4.9 | 24,650 | Common Stock |
| Sharon Hrynkow | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 4.98 per share. | 02 Dec 2021 | 1,000 | 19,350 | - | 5.0 | 4,980 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 02 Dec 2021 | 4,136 | 97,347 | - | 4.8 | 19,646 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 5.00 per share. | 01 Dec 2021 | 5,000 | 93,211 | - | 5 | 25,000 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 5.25 per share. | 19 Nov 2021 | 5,000 | 119,666 | - | 5.3 | 26,250 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 5.25 per share. | 19 Nov 2021 | 10,000 | 88,211 | - | 5.3 | 52,500 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 5.22 per share. | 19 Nov 2021 | 652 | 78,211 | - | 5.2 | 3,403 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 5.90 per share. | 29 Oct 2021 | 1,000 | 77,559 | - | 5.9 | 5,900 | Common Stock |
| Lise Lund Kjems | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2021 | 17,053 | 17,053 | - | 0 | Common Stock | |
| Lise Lund Kjems | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2021 | 23,800 | 23,800 | - | - | Stock Option (Right to buy) | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 6.35 per share. | 15 Sep 2021 | 5,000 | 114,666 | - | 6.4 | 31,750 | Common Stock |
| C.E. Rick Strattan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| William S. Shanahan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| N. Scott Fine | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 57,300 | 57,300 | - | - | Stock Option (Right to buy) | |
| Markus Sieger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 23,800 | 23,800 | - | - | Stock Option (Right to buy) | |
| Sharon Hrynkow | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 23,800 | 23,800 | - | - | Stock Option (Right to buy) | |
| Joshua M. Fine | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 23,800 | 23,800 | - | - | Stock Option (Right to buy) | |
| F. Patrick Ostronic | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| Randall M. Toig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 6,700 | 6,700 | - | - | Stock Option (Right to buy) | |
| Michael Lisjak | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Aug 2021 | 23,800 | 23,800 | - | - | Stock Option (Right to buy) | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2021 | 2,500 | 40,000 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Jun 2021 | 7,500 | 37,500 | - | - | Warrant to Purchase Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 Jun 2021 | 100 | 100 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 21 May 2021 | 3,482 | 30,000 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 21 May 2021 | 2,312 | 26,518 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 21 May 2021 | 9,206 | 24,206 | - | - | Warrant to Purchase Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 6.75 per share. | 16 Apr 2021 | 5,000 | 71,559 | - | 6.8 | 33,750 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 6.30 per share. | 16 Apr 2021 | 5,000 | 76,559 | - | 6.3 | 31,500 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 7.00 per share. | 12 Apr 2021 | 5,000 | 66,559 | - | 7 | 35,000 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 8.10 per share. | 29 Mar 2021 | 10,000 | 67,614 | - | 8.1 | 81,000 | Common Stock |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 7.50 per share. | 29 Mar 2021 | 2,000 | 27,160 | - | 7.5 | 15,000 | Common Stock |
| Sharon Hrynkow | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 7.46 per share. | 29 Mar 2021 | 1,000 | 18,350 | - | 7.5 | 7,460 | Common Stock |
| Joshua M. Fine | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 7.40 per share. | 29 Mar 2021 | 50 | 16,900 | - | 7.4 | 370 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 7.60 per share. | 29 Mar 2021 | 2,000 | 61,559 | - | 7.6 | 15,200 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 7.40 per share. | 29 Mar 2021 | 1,000 | 59,559 | - | 7.4 | 7,400 | Common Stock |
| Randall M. Toig | Director | 05 Mar 2021 | 10,000 | 0 | - | - | Warrant to Purchase Common Stock | ||
| Randall M. Toig | Director | 05 Mar 2021 | 10,000 | 44,078 | - | 5 | 50,000 | Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 6.35 per share. | 25 Jan 2021 | 1,400 | 52,013 | - | 6.4 | 8,890 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 6.60 per share. | 25 Jan 2021 | 2,201 | 57,614 | - | 6.6 | 14,527 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 6.36 per share. | 25 Jan 2021 | 3,400 | 55,413 | - | 6.4 | 21,624 | Common Stock |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 6.20 per share. | 25 Jan 2021 | 2,999 | 50,613 | - | 6.2 | 18,594 | Common Stock |
| N. Scott Fine | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2021 | 10,000 | 109,666 | - | 0 | Common Stock | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2021 | 10,000 | 25,160 | - | 0 | Common Stock | |
| Sharon Hrynkow | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2021 | 10,000 | 17,350 | - | 0 | Common Stock | |
| Joshua M. Fine | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2021 | 10,000 | 16,850 | - | 0 | Common Stock | |
| Michael Lisjak | Chief Regulatory Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2021 | 10,000 | 12,400 | - | 0 | Common Stock | |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.70 per share. | 17 Dec 2020 | 19,800 | 58,559 | - | 4.7 | 93,060 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.69 per share. | 17 Dec 2020 | 200 | 38,759 | - | 4.7 | 938 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.60 per share. | 17 Dec 2020 | 5,000 | 38,559 | - | 4.6 | 23,000 | Common Stock |
| F. Patrick Ostronic | Director | Purchase of securities on an exchange or from another person at price $ 4.55 per share. | 17 Dec 2020 | 5,000 | 33,559 | - | 4.6 | 22,750 | Common Stock |
| William S. Shanahan | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 20,000 | 20,000 | - | - | Warrant to Purchase Common Stock | |
| William S. Shanahan | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 20,000 | 63,677 | - | - | Common Stock | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 20,000 | 99,666 | - | - | Common Stock | |
| N. Scott Fine | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 20,000 | 20,000 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 15,000 | 15,000 | - | - | Warrant to Purchase Common Stock | |
| Markus Sieger | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 15,000 | 72,729 | - | - | Common Stock | |
| Jeffrey Tate | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 5,000 | 15,160 | - | - | Common Stock | |
| Jeffrey Tate | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 5,000 | 5,000 | - | - | Warrant to Purchase Common Stock | |
| Sharon Hrynkow | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 1,000 | 1,000 | - | - | Warrant to Purchase Common Stock | |
| Sharon Hrynkow | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 1,000 | 7,350 | - | - | Common Stock | |
| Randall M. Toig | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 10,000 | 34,078 | - | - | Common Stock | |
| Randall M. Toig | Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Dec 2020 | 10,000 | 10,000 | - | - | Warrant to Purchase Common Stock | |
| Joshua M. Fine | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.08 per share. | 23 Nov 2020 | 15,000 | 685,000 | - | 0.1 | 1,125 | Common Stock |
| Joshua M. Fine | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.08 per share. | 23 Nov 2020 | 10,000 | 670,000 | - | 0.1 | 799 | Common Stock |
| C.E. Rick Strattan | Director, CHIEF EXECUTIVE OFFICER, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Jul 2012 | 20,000 | 18,678,758 | - | - | COMMON STOCK | |
| C.E. Rick Strattan | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Sep 2010 | 5,000 | 17,771,650 | - | - | Common Stock | |
| C.E. Rick Strattan | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Sep 2010 | 1,000 | 17,770,650 | - | - | Common Stock | |
| C.E. Rick Strattan | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Sep 2010 | 5,000 | 17,765,650 | - | - | Common Stock | |
| C.E. Rick Strattan | Director, PRESIDENT CEO, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Feb 2004 | 150,000 | 3,136,000 | - | - | COMMON SHARES | |
| C.E. Rick Strattan | Director, PRESIDENT CEO, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Feb 2004 | 50,000 | 3,086,000 | - | - | COMMON SHARES | |
| C.E. Rick Strattan | Director, PRESIDENT CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 Nov 2003 | 100,000 | 2,400,000 | - | - | COMMON SHARES |